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Found 47 dataset(s) matching "pharmacokinetics".
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Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for...
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Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
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Background It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be...
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This data set includes source code files and associated data files that implement a pharmacokinetic (PK) model for lipophilic persistent environmental chemicals (LPECs) that can be used to...
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Background PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the...
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How to access data for "Decrane R, Stoker T, Murr A, Ford J, El-Masri H. Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data,...
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Generic physiologically-based pharmacokinetic (PBPK) models were used to explore how saturable absorption or clearance can influence the shape of the internal to external concentration (IEC)...
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Estimates of ionization equilibrium constants (i.e., pKa) were analyzed for 8,132 pharmaceuticals and 24,281 other compounds to which humans might be exposed in the environment. Results revealed...
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This is a new, open, and transparent database of toxicokinetic data supporting EPA decision making. The database has already become the basis of research efforts within EPA to improve HTTK...
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Publicly available dataset containing chemical exposure data. This dataset is associated with the following publication: Lin, Y., V. Morozov, A. Kadry, J. Caffrey , and W. Chou. Reconstructing...
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This dataset is a collection of .csv's for extracted data from the literature, processing code, and final analysis for manuscript. This dataset is not publicly accessible because: This data is...
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Background A study for pain relief therapy with 188Re-HEDP was done in patients with bone metastases secondary to breast and prostate cancer. Materials and...
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General aggregate PFOS and PFOA exposure estimates are based on reported summary statistics from concentration studies by media, i.e. into indoor air, outdoor air, food, water, dust and soil, and...
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Background Artesunate is a commonly used antimalarial drug derived from artemisinin. It is rapidly converted to dihydroartemisinin. Little is known on this conversion in the GI tract and...
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This ScienceHub entry contains a zip file with the pharmacokinetic modeling code used for the linked publication, "Challenges for extrapolation of risk from ingestion to inhalation exposure for...
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This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC...
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Background Most test systems for acetylcholinesterase activity (E.C.3.1.1.7.) are using toxic inhibitors (BW284c51 and iso-OMPA) to distinguish the enzyme from butyrylcholinesterase...
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The present invention relates to an orally available galenics formulation of Valproic Acid or derivatives thereof exhibiting a specific bi-phasic pharmacokinetic profile optimized for maximum...
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File contains raw data collected on body and organ weights of mice given PFBS and body burden of the chemical after intervals of several hours, as well as expression of liver candidate genes for...
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This ScienceHub entry was developed for the published paper: Consoer et al., 2016, Toxicokinetics of perfluorooctane sulfonate in rainow trout (Oncorhynchus mykiss), Environ. Toxicol. Chem....
