Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals

This is a new, open, and transparent database of toxicokinetic data supporting EPA decision making. The database has already become the basis of research efforts within EPA to improve HTTK modeling using generic TK models and has facilitated the creation and validation of models for new exposure routes. Publishing the database supports open, transparent science and this database (the largest public database for this domain) will spur improvement and development of TK models by external experts in the field. Future efforts to improving the accessibility of this database (with a graphical user interface) and encouraging crowdsourcing to expand the size and scope of the database will lead to larger validation sets for our modeling efforts and likely lower uncertainties when estimating TK. This dataset is associated with the following publication: Sayre, R., J. Wambaugh, and C. Grulke. Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals. Scientific Data. Springer Nature Group, New York, NY, 7: 122, (2020).

[
  "020:00"
]

[
  "020:095"
]

[
  "https://doi.org/10.1038/s41597-020-0455-1"
]