Search Data.gov
Found 31 dataset(s) matching "pbpk".
-
The data set includes source code that implements a PBPK model template that has been extended with features capable of implementing models for volatile organic compounds (VOCs). It also includes...
-
The data set includes source code that implements a PBPK template model applicable to PFAS. It includes data digitized from Kim et al. (2018), Kim et al. (2019), and Loccisano et al. (2012) used...
-
How to access data for "Decrane R, Stoker T, Murr A, Ford J, El-Masri H. Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data,...
-
The data set includes source code for a "PBPK model template" that can be used to implement physiologically based pharmacokinetic (PBPK) models with various different structural designs and...
-
Source Code for the manuscript "Characterizing Variability and Uncertainty for Parameter Subset Selection in PBPK Models" -- This R code generates the results presented in this manuscript; the...
-
Contains values from pbpk models for each study on n-butanol effects. This dataset is associated with the following publication: Segal, D., A. Bale, L. Phillips, A. Sasso, P. Schlosser, C....
-
This data set includes source code that implements a PBPK model for naphthalene that allows for inhalation and skin routes of exposure. It also includes data previously published by Kim et al....
-
The dataset includes source code that was used to perform analyses described in the manuscript "Evaluating Impact of Anatomical and Physiological Variability on Human Equivalent Doses Using PBPK...
-
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for...
-
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
-
Generic physiologically-based pharmacokinetic (PBPK) models were used to explore how saturable absorption or clearance can influence the shape of the internal to external concentration (IEC)...
-
Background It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be...
-
MCSimMod is a flexible and efficient R package that can be used for implementation and application of physiologically based pharmacokinetic (PBPK) and other ordinary differential equation (ODE) models.
-
Background PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the...
-
Dataset is a time course description of lindane disappearance in blood plasma after dermal exposure in human volunteers. This dataset is associated with the following publication: Sawyer, M.E.,...
-
This dataset describes disappearance of chloroform from a vapor uptake chamber with time due to metabolism. The research concentrates on optimization for estimation of metabolic constants using a...
-
Perchlorate is an environmental contaminant that interferes with iodine uptake via the NIS transporter into the thyroid gland, reducing thyroid hormone (TH) synthesis. As adequate supplies of TH...
-
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC...
-
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
