Search Data.gov
Found 110 dataset(s) matching "Mechanism of Action".
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Background Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the...
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Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay using H295R human...
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The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling...
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Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed in the treatment of...
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Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search...
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This study examined effects of the brominated flame retardant hexabromocyclododecane (HBCD) on the avian endocrine system. Japanese quail (Coturnix japonica) were exposed to multiple doses of HBCD...
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In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with...
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Transformed cells obtained by transferring into normal cells with a gene encoding a protein capable of phosphorylation of p38 protein, or the p38 protein, a variant of the p38 protein, the kinase...
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A multi-stage process is claimed for preparing 2-amino-3-(2-(substituted ethyl)-3-oxo-3,4-dihydro-2H-benz-(1,4)-oxazin-6-yl)-propionic acid derivatives (I), starting from...
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Background Chemotherapy is important in the systematic treatment of breast cancer. To enhance the response of tumours to chemotherapy, attention has been focused on agents to reverse...
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Exposure to weightlessness in microgravity and elevated space radiation are associated with rapid bone loss in mammals, but questions remain about their mechanisms of action and relative...
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A silicone paint comprises polyorganosiloxane containing at least two unsaturated groups in the molecule; a polyorganohydrogensiloxane containing at least two silicone hydride groups in the...
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Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density...
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A cosmetic or dermatological composition contains by weight (a) a red light-filtering colorant (0.01-5%); and (b) an antiinflammatory agent (0.0001-10%). ACTIVITY : Dermatological;...
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The eastern oyster (Crassostrea virginica) supports a large aquaculture industry and is a keystone species along the Atlantic seaboard. Native oysters are routinely exposed to a complex mixture of...
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Pyrimidine derivatives (I) are used as acetylcholinesterase inhibitors. Pyrimidine derivatives of formula (I) are used as acetylcholinesterase inhibitors. R 1, R 3 = H or optionally unsaturated...
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Aqueous composition (A) for inhalation contains as only active ingredient a tricyclo-oxa-aza-nonane derivative (I), at least one acid and optionally other auxiliaries and/or complexing agents....
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Recognition molecules (RM), especially antibodies (A) that bind specifically to the Core-1 (C1) antigen, comprising defined amino acids sequences (1-6) given in the specification and below, are...
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In the field of tissue engineering, 3D scaffolds and cells are often combined to yield constructs that are used as therapeutics to repair or restore tissue function in patients. Viable cells are...
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Peptides (I) (of six sequences (GPR7 ligands A through F) of human, mouse, rat and bovine origin, given in the specification) which bind to the GPR7 opioid-somatostatin-like receptor protein, and...
