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Found 27 dataset(s) matching "Endocrine Disruptors".
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A liquid chromatogrpahy mass spectrometry (LC-MS) method was developed for the analysis of 13 endogenous steroids. The method was validated using both fish plasma and fish holding water. The...
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This high-throughput method will be useful in rapid evaluation of chemicals for nuclear receptor activity for multiple species of interest. The modular design of the assay also permits ready...
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These data are from two studies conducted to evaluate the performance of the draft Larval Amphibian Growth and Development Assay for incorporation into the U.S. EPA's Endocrine Disruptor Screening...
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Five chemicals [2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 4-nonylphenol-branched (4-NP), 4-tert-octylphenol (4-OP), benzyl butyl phthalate (BBP) and dibutyl phthalate (DBP) were subjected to a...
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In response to various legislative mandates the United States Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, implemented a tiered...
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Evaluation of multigenerational effects of 2-ethylhexyl 4-hydroxybenzoate in Japanese medaka Abstract The Japanese medaka (Oryzias latipes) extended one-generation reproduction test (MEOGRT)...
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Mercury is a globally distributed pollutant that threatens human and ecosystem health. Even protected areas, such as national parks, are subjected to mercury contamination because it is delivered...
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There is an increasing emphasis on effects-based monitoring to document responses associated with exposure to complex mixtures of chemicals, climate change, pathogens, parasites and other...
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This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test chemicals were selected to...
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This paper presents data from studies performed to satisfy test orders from the US EPA’s Endocrine Disruptor Screening Program. Data Evaluation Records were used to collate the control variability...
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Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
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A diverse data set of 1667 chemicals with AR experimental activity were provided by the U.S. EPA from the oxicity Forecaster (ToxCast) program which generates data using in vitro high-throughput...
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Dataset consists of high throughput in vitro bioactivity data and exposure predictions from the U.S. EPA’s Toxicity and Exposure Forecaster (ToxCast and ExpoCast) project. This dataset is...
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Biological indicators including morphometric (length, weight), age, sex and health indicators including organismal (health assessment index, condition factor), organ (hepatosomatic index,...
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The greater dynamic range of testosterone production in a highly purified rat Leydig cell assay permitted the detection of chemical induced inhibition that was not detected by the high throughput...
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Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This dataset is associated with the...
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Final Data SeqAPASS v3.0.zip contains datasets from Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool versions 3.0 for all 497 proteins evaluated using Level 1 (primary...
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A representative group of multicyclic aromatic hydrocarbons (MAHC) which can be further classified as bridged-ring (bridged-MAHC) or fused-ring (fused-MAHC) were examined for their ability to...
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Table S1. All chemicals and AC50 from invitrodb v3 for human FACTORIAL-TRANS assay endpoints. Table S2. Agreement with OECD reference AR agonists. Table S3. Agreement with OECD reference ER...
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Dataset for the publication "Expanded High-Throughput Screening and Chemotype-Enrichment Analysis of the Phase II:e1k ToxCast Library for Human Sodium-Iodide Symporter (NIS)...
