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Found 54 dataset(s) matching "Adverse Outcome Pathways (AOPs)".
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A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in an AOP network. While there...
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A publised mansucript describing a quantitative adverse outcome pathway (qAOP) and its relevance to risk assessment. This dataset is not publicly accessible because: This work describes...
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Ongoing honey bee colony losses are of significant international concern because of the essential role these insects play in pollinating many high nutrient crops, such as fruits, vegetables, and...
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The majority of this dataset includes the query output from online databases ECOTOX and SeqAPASS used to support the ecological AOP case studies described within the manuscript. The final...
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The EPA has developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Since...
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Our ability to conduct whole organism toxicity tests to understand chemical safety has been outpaced by our ability to synthesize new chemicals for a wide variety of commercial applications. ...
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Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the utility of a simple AOP network...
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Table of contents Table S1 DNT inventory List of sources and associated data collected for the development of the Bayesian hierarchical model. Table S2 Data...
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Adequate levels of thyroid hormones (TH) are needed for proper brain development, deficiencies may lead to adverse neurological outcomes in humans and animal models. Environmental chemicals have...
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The data set provides a set of txt files and cytoscape files that were used to construct the example AOP networks included in the paper. Additionally, a supplementary table file provides all the...
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Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations that elicit cytotoxicity, and a...
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Metabolite Input Files for Determining Biochemical Pathways Impacted by Spironolactone Exposures of Fathead Minnows (Pimephales promelas) Using the Mummichog Software package. This dataset is...
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Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
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This data set contains dose-response data for perchlorate exposure in multiple species. These data were assembled from peer-reviewed studies. Species included in this dataset are: rats (Rattus...
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This dataset describes concentrations of DEHP in numerous types of environmental, biological, and manufactured media, along with rates of transformation and transportation. The references used to...
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In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in experiments in which...
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This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo) responses to...
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Since the publication of the Adverse Outcome Pathway (AOP) for skin sensitization, there have been many efforts to develop systematic approaches to integrate the information generated from...
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Phenones and hydroxy benzophenones are widely used as UV radiation filters, and in the manufacturing of insecticides and pharmaceuticals. Understanding the ability of these chemicals to mimic the...
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The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database containing all literature that was...
