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Found 75 dataset(s) matching "AOP".
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The EPA has developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Since...
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This dataset contains ontology terms associated with key events from the AOP-Wiki. This information was used to seed the AOP-Wiki with a carefully selected set of ontology terms prior to opening...
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The data set consists of the following: 1) AOP-Wiki xml downloads from March 2022 used in constructing and evaluating the AOP network. 2) A literature database containing all literature that was...
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The majority of this dataset includes the query output from online databases ECOTOX and SeqAPASS used to support the ecological AOP case studies described within the manuscript. The final...
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Toward an AOP Network-based tiered testing strategy for the assessment of thyroid hormone disruption
No novel data were reported in association with this product. This dataset is not publicly accessible because: The associated publication is a review/forum-type article. No novel scientific data...
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Neurotox data on in silico predicted chemicals to cause protein adducts in peripheral neurons. Includes cytotoxicity (LDH release), changes in neuron network architecture using high content...
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Our ability to conduct whole organism toxicity tests to understand chemical safety has been outpaced by our ability to synthesize new chemicals for a wide variety of commercial applications. ...
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Ongoing honey bee colony losses are of significant international concern because of the essential role these insects play in pollinating many high nutrient crops, such as fruits, vegetables, and...
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Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the utility of a simple AOP network...
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A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in an AOP network. While there...
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Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations that elicit cytotoxicity, and a...
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This dataset provides USFS Aquatic Organism Passage (AOP) survey data. It shows stream passage locations, passage measurements, and passability assessment categories from AOP field surveys....
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In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in experiments in which...
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This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo) responses to...
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Since the publication of the Adverse Outcome Pathway (AOP) for skin sensitization, there have been many efforts to develop systematic approaches to integrate the information generated from...
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<p>Tabular data from the manuscript "Monitoring standing herbaceous biomass and thresholds in semiarid rangelands from harmonized Landsat 8 and Sentinel-2 imagery to support within-season adaptive...
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Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
