Results from application of Approximate Probabilistic Analysis to incidence of nasal lesions from acrolein exposure

For estimating the distribution of the target human dose for magnitude of effect M and human incidence I (abbreviated “HDMI”) in the Approximate Probabilistic Analysis (APROBA) software tool, using the default assumptions in APROBA (primary analysis) and specific case adjustments (sensitivity analyses): 1) Confidence limits of the HDMI components that were input in APROBA for each analysis, and the confidence limits for the estimated HDMI distributions that were output, along with some supplementary calculations on the outputs. Also included for each analysis are the percents contribution of the HDMI components to HDMI uncertainty. 2) Results of Bayesian model averaging dose-response analysis of incidence of nasal lesions in the lateral wall at level II, used for the sensitivity analysis in which dose-response modeling was used to determine the point of departure. 3) Parameters of the HDMI distribution for varying values of human incidence I. This dataset is associated with the following publication: Blessinger, T., A. Davis, W. Chiu, J. Stanek, G. Woodall, J. Gift, K. Thayer, and D. Bussard. Application of a Unified Probabilistic Framework to the Dose-Response Assessment of Acrolein. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 143: 105953, (2020).

[
  "020:00"
]

[
  "020:062"
]

[
  "https://doi.org/10.1016/j.envint.2020.105953"
]