RAD51 Interconnects Between DNA Replication DNA Repair and Immunity

Published by National Aeronautics and Space Administration | National Aeronautics and Space Administration | Metadata Last Checked: October 02, 2025 | Last Modified: 2025-04-23

RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm triggering a STING-mediated innate immune response after replication stress and DNA damage. Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing RAD51 is also implicated in the suppression of innate immunity. Thus our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling placing it at the hub of new interconnections between DNA replication DNA repair and immunity. Overall design Gene expression analysis of WT and sh RAD51 HT1080 cells was carried out before and after 1 Gy of high LET Fe particle radiation.

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Complete Metadata

bureauCode	[ "026:00" ]
identifier	nasa_genelab_GLDS-130_xkj4-wfuy
issued	2018-06-26
landingPage	https://data.nasa.gov/dataset/rad51-interconnects-between-dna-replication-dna-repair-and-immunity
programCode	[ "026:005" ]
theme	[ "Earth Science" ]