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Physiologic role of interleukin-1 receptor antagonist
Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit the excess amounts of locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may predispose to local inflammatory disease in particular tissues in the presence of other as yet unknown genetically influenced factors.
Complete Metadata
| bureauCode |
[ "009:25" ] |
|---|---|
| identifier | https://healthdata.gov/api/views/rtpz-qkpv |
| issued | 2025-07-14 |
| landingPage | https://healthdata.gov/d/rtpz-qkpv |
| programCode |
[ "009:033" ] |
| theme |
[ "NIH" ] |
