Patent AT-E40139-T1: [Translated] PROCESS FOR THE PRODUCTION OF PURE ANDROST-2ENDED DERIVATIVES.

1. A process for producing a DELTA-2 androstenic derivative in the pure state form a mixture of DELTA-2(3) and DELTA-3(4) androstene characterized in that a mixture of Androstenes of the formula see diagramm : EP0200591,P8,F1 wherein the dotted line symbolizes a double bond in the position 2(3) or 3(4) R is a, free esterified with an organic acid having from 1 to 10 carbon atoms or etherified with an alkyl radical or a tetrahydropyranyl, hydroxyl group R' is hydrogen, a lower alkenyl radical, a lower alkynyl radical, a lower alkyl radical a phenyl radical or a cycloalkyl radical or R and R' together are the oxygen of a ketonic group and the wawed line indicates the spatial orientation alpha or beta is submitted to the action of a sulfonating agent pure or in an inert solvent in the optional presence of a dehydrating agent, to obtain a DELTA-3 Androstenyl 2-sulfonic acid of the general formula II see diagramm : EP0200591,P8,F3 in which R and R' have the previously given meanings and recovers the pure DELTA-2 androstenic derivative, unaltered having the general formula IV see diagramm : EP0200591,P8,F2 wherein the substituents R and R' are defined as previous by given.

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  "NIH"
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