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Patent AT-E401348-T1: [Translated] IMMUNOCONJUGATES WITH HIGH BINDING AFFINITY
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
Complete Metadata
| bureauCode |
[ "009:25" ] |
|---|---|
| identifier | https://healthdata.gov/api/views/x2yf-jjda |
| issued | 2025-09-05 |
| landingPage | https://healthdata.gov/d/x2yf-jjda |
| programCode |
[ "009:066" ] |
| theme |
[ "NIH" ] |
