Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: June 27, 2025 | Last Modified: 2019-03-05

The Tox21 chemical library (8,305 unique structures) was screened in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active compounds were further characterized using additional orthogonal assays, including mammalian one-hybrid assays, coactivator recruitment assays, and a high-throughput, fluorescent imaging, nuclear receptor translocation assay. Results for the library are available at https://tripod.nih.gov/tox21/samples. This dataset is associated with the following publication: Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, and K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 127(9): 1-16, (2019).

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Complete Metadata

bureauCode	[ "020:00" ]
identifier	https://doi.org/10.23719/1503082
programCode	[ "020:095" ]
references	[ "https://doi.org/10.1289/ehp5314" ]
rights	null