HARV replication of the BRIC-23 Bacillus subtilis spaceflight

Published by National Aeronautics and Space Administration | National Aeronautics and Space Administration | Metadata Last Checked: October 20, 2025 | Last Modified: 2025-04-23

Previous spaceflight experiments using Bacillus subtilis have reported altered transcriptome profiles during spaceflight compared to matching ground samples. This study tried to replicate those transcriptome changes using High Aspect Ratio Vessels (HARVs). B. subtilis spores were grown in HARVs using the same protocol and growth conditions as the BRIC-23 spaceflight mission. RNA was extracted from the HARV samples and sequenced for differential expression analysis. HARV differentially expressed genes were then compared to the genes identified as differentially expressed in the BRIC-23 mission to access the accuracy of HARVs as a model for spaceflight experiments.

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Complete Metadata

bureauCode	[ "026:00" ]
identifier	nasa_genelab_GLDS-216_saqd-3ded
issued	2021-05-21
landingPage	https://data.nasa.gov/dataset/harv-replication-of-the-bric-23-bacillus-subtilis-spaceflight
programCode	[ "026:005" ]
theme	[ "Earth Science" ]