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Genomic functional annotation using co-evolution profiles of gene clusters

Published by National Institutes of Health | U.S. Department of Health & Human Services | Metadata Last Checked: September 06, 2025 | Last Modified: 2025-09-06
The current speed of sequencing already exceeds the capability of annotation. A new method for functional annotation is proposed using the conservation patterns of gene clusters and has been applied to the genome of Escherichia coli and established functional relationships among 176 gene clusters, comprising 738 genes.

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