Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation

Published by National Aeronautics and Space Administration | National Aeronautics and Space Administration | Metadata Last Checked: June 28, 2025 | Last Modified: 2025-04-23

Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions. 129S2 K-rasLA1 mice were either irradiated with an acute (1.0Gy x1; n = 15) or fractionated (0.2Gy x5; n=13) dose of 1.0Gy 56Fe- particles or left unirradiated (n=13). Animals were euthanized 70 days post-irradiation and RNA was extracted from the whole left lung of each animal.

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Complete Metadata

bureauCode	[ "026:00" ]
identifier	nasa_genelab_GLDS-148_vy43-qjx6
issued	2018-06-26
landingPage	https://data.nasa.gov/dataset/expression-profiling-of-murine-lung-70-days-following-exposure-to-fractionated-or-acute-do
programCode	[ "026:005" ]
theme	[ "Earth Science" ]