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Endothelial [Ca2+]iis an integrating signal for the vascular tone in rat aortae

Published by National Institutes of Health | U.S. Department of Health & Human Services | Metadata Last Checked: September 30, 2025 | Last Modified: 2025-09-29
Although various endothelium-dependent relaxing factors (endothelial autacoids) are released upon the elevation of endothelial cytosolic free Ca2+concentration (EC [Ca2+]i), the quantitative relationship between EC [Ca2+]iand vascular tone remains to be established. Moreover, whether the basal release of endothelial autacoids is modulated by basal EC [Ca2+]iis still unclear. We assessed these issues by using a novel method that allows simultaneous recording of EC [Ca2+]iand vascular displacement in dissected rat aortic segments.

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