Effects of metformin and its metabolite guanylurea on fathead minnow (Pimephales promelas) reproduction

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: June 27, 2025 | Last Modified: 2022-07-01

Data associated with exposures of fathead minnows to varying concentrations of metformin and/or guanylurea. Includes three individual studies: ex vivo steroidogenesis assay, 96 h time course assay, 23 d reproduction assay. This dataset is associated with the following publication: Blackwell, B., G. Ankley, A. Biales, J. Cavallin, A. Cole, T. Collette, D. Ekman, R. Hofer, W. Huang, K. Jensen, M. Kahl, A. Kittelson, S. Romano, M. See, Q. Teng, C. Tilton, and D. Villeneuve. Effects of Metformin and its Metabolite Guanylurea on Fathead Minnow (Pimephales promelas) Reproduction (FY22 Manuscript). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 41(11): 2708-2720, (2022).

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Complete Metadata

bureauCode	[ "020:00" ]
identifier	https://doi.org/10.23719/1526538
programCode	[ "020:000" ]
references	[ "https://doi.org/10.1002/etc.5450" ]
rights	null