Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression

Published by National Aeronautics and Space Administration | National Aeronautics and Space Administration | Metadata Last Checked: June 28, 2025 | Last Modified: 2025-04-23

Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of ability to transition between lipid and glucose as energy source (metabolic inflexibility) was investigated by hind-limb suspension (HLS) treatment of Male ICR mice (28 x9632 g body wt; Harlan Indianapolis IN). Agilent Whole Mouse Genome Oligo Microarrays were utilised to examine the effects of HLS on mRNA expression profiles of the soleus muscle and the gastrocnemius muscle in the hindlimbs of freely ambulating control and 24h HLS treated mice.

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Complete Metadata

bureauCode	[ "026:00" ]
identifier	nasa_genelab_GLDS-227_gdv2-w3kb
issued	2021-05-21
landingPage	https://data.nasa.gov/dataset/effect-of-acute-muscle-unloading-on-soleus-and-gastrocnemius-muscle-gene-expression
programCode	[ "026:005" ]
theme	[ "Earth Science" ]