A study of alterations DNA epigenetic modifiincations (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells

Published by National Aeronautics and Space Administration | National Aeronautics and Space Administration | Metadata Last Checked: June 28, 2025 | Last Modified: 2025-04-23

Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of 2 different DNA modifications with 2 replicates each for 1 cell type.

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Complete Metadata

bureauCode	[ "026:00" ]
identifier	nasa_genelab_GLDS-86_yu6a-h5vm
issued	2021-05-21
landingPage	https://data.nasa.gov/dataset/a-study-of-alterations-dna-epigenetic-modifiincations-5mc-and-5hmc-influenced-by-simulated
programCode	[ "026:005" ]
theme	[ "Earth Science" ]