Catalog - Data.gov

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 10:03 AM

Background Vaccinia virus gene B1R encodes a serine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R,...

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Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:27 AM

Background Viral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding...

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Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:34 AM

Background Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on...

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Synthesis of a novel hepatitis C virus protein by ribosomal frameshift

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 05:33 AM

Hepatitis C virus (HCV) is an important human pathogen that affects ∼100 million people worldwide. Its RNA genome codes for a polyprotein, which is cleaved by viral and cellular proteases to...

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Binding of the baculovirus very late expression factor 1 (VLF-1) to different DNA structures

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 07:21 AM

Background Baculovirus genomes encode a gene called very late expression factor 1 (VLF-1) that is a member of the integrase (Int) family of proteins. In this report we describe the...

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