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Found 2 dataset(s) matching "shared-epitope".

B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response
- Organization: U.S. Department of Health & Human Services
- Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:11 AM
The influence of HLA DRB1 alleles on B-cell homeostasis was analyzed in 164 patients with rheumatoid arthritis (RA). The percentages of CD19+ B lymphocytes determined in the peripheral circulation...
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Association of MHC and rheumatoid arthritis: Association of RA with HLA-DR4 - the role of repertoire selection
- Organization: U.S. Department of Health & Human Services
- Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:44 AM
Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In...
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