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Found 16 dataset(s) matching "molecular initiating events".
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Modeling data and analysis scripts generated during the current study are available in the github repository: https://github.com/USEPA/CompTox-MIEML. RefChemDB is available for download as...
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Adult fathead minnows were exposed to dilutions of a historically estrogenic wastewater treatment plant effluent in a 21-d reproduction study. This dataset is comprised of a variety of endpoints...
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Although endocrine disrupting compounds have been detected in wastewater and surface waters worldwide using a variety of in vitro effects-based screening tools, e.g. bioassays, few have examined...
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This excel file contains the resultant data from a study on iodotyrosine deiodinase in the model amphibian species, Xenopus laevis. These data include: tadpole growth and development, thyroid...
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High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge on perturbed thyroid hormone...
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In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in experiments in which...
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The US EPA Toxicity Forecasting (ToxCast) project has involved the generation of large amount of high throughput in vitro data (Over 4000 chemicals tested in between 100 and 700 assays). This data...
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Microarray experiments used in the study. This dataset is associated with the following publication: Corton, J., T. Hill, J. Sutherland, J. Stevens, and J. Rooney. A Set of Six Gene Expression...
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The microarray experiments used in the study. This dataset is associated with the following publication: Hill, T., J. Rooney, J. Abedini, H. El-Masri, C. Wood, and J. Corton. Gene Expression...
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Reef-building corals (Orbicella faveolata) were sampled at both inshore (The Rocks and Cheeca Rocks) and offshore reefs (Little Conch and Crocker Reef) under Florida Keys National Marine Sanctuary...
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Given the widespread decline of coral reefs across the globe on account of climate change-induced rises in seawater temperature, a series of temperature-focused models have been generated to...
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Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both position effects...
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Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid...
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Background Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model organism Caenorhabditis...
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This contains some of the results from the first high spatial resolution X-ray study of the massive star-forming region NGC 6357, which were obtained in a 38 ks Chandra/ACIS observation. Inside...
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Data were collected as part of a study to identify sources of E. coli contamination at several beaches located in the Grand Calumet River Areas of Concern, located in northern Indiana on Lake...
