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Found 91 dataset(s) matching "in vitro screening".
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Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro screening assays through...
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This data includes metabolite predictions for in vitro inactive chemicals, predictions of those metabolite's estrogen receptor binding activity, in vitro and in silico information regarding parent...
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Data describe the effects of metal oxide nanoparticles on total spikes and active electrodes after exposure to various concentrations for 1, 24 and 48 hrs, or after treatment with bicuculline....
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Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence....
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This data set is a dose response analysis of two thyroid hormone synthesis disruptors in adult male rats. Data included serum and thyroid gland concentrations of the two chemicals tested,...
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In vitro bioactivity concentrations and chemical concentrations of estrogens, androgens, and glucocorticoids from a nationwide screen of United States stream water samples. In vitro bioassays...
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The objective of this study was to develop a medium-throughput organotypic screening assay comprised of reconstructed human thyroid microtissues to quantitatively evaluate the disruptive effects...
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Aromatase inhibition is one of the chemical modes of action of concern to EPA's Endocrine Disruptor Screening Program (EDSP). In vitro bioassays that can detect aromatase inhibition are part of...
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Background: Chemicals in consumer products are a major contributor to human chemical co-exposures. Consumers purchase and use a wide variety of products containing potentially thousands of...
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Dataset for 'Evaluation of a high-throughput H295R homogenous time resolved fluorescence assay for androgen and estrogen steroidogenesis screening', Garnovskaya, et al., Toxicology in Vitro, Vol...
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Tapwater samples from residential and commercial sites were sampled in Puerto Rico in August 2018 in a pilot study. All samples were screened using estrogen, androgen and glucocorticoid in vitro...
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The excel spreadsheet contains the resultant data from an assay for chemical inhibition of human Iodotyrosine Deiodinase (IYD) enzyme activity screened against the ToxCast Phase 1_v2, Phase 2, and...
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This research was designed to evaluate whether a biologically-based computational model aligned with an adverse outcome pathway (AOP) could effectively predict animal (in vivo) responses to...
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A single excel file describes data from the manuscript entitled In vitro effects-based method and water quality screening model for use in pre- and post-distribution treated waters. The file is...
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Gene expression data from the Fluidigm qRT-PCR arrays was analyzed in R (v3.6.1; R Foundation for Statistical Computing, 2019). Prior to processing through the tcpl package, each qRT-PCR primer...
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Results of single concentration and concentration response testing of 165 PFAS samples from the USEPA ToxCast chemical library in nine (9) thyroid relevant assays. Chemicals were first screened in...
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the zip files contain outputs from the R-analysis for the nanosilver experiments. This dataset is associated with the following publication: Strickland, J., W. LeFew, J. Crooks, D. Hall, J....
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The ToxCast program has generated in vitro screening data on over a thousand chemicals to assess potential disruption of important biological processes and assist in hazard identification and...
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We use a supervised machine learning strategy to systematically investigate the relative importance of study type, machine learning algorithm, and type of descriptor on predicting in vivo...
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Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and hypospadias, which have been associated...
