Catalog - Data.gov

Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: an

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 05:11 AM

Background The role of telomerase activation in the expression and/or maintenance of drug resistance is not clearly understood. Therefore, we investigated the relationships, among the...

html

Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:14 AM

Background Acyclovir (ACV) resistant herpes simplex virus (HSV) isolates can be readily selected in animal infection models receiving suboptimal ACV treatment, however no comparative...

html

Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:08 AM

Background The routine determination of drug resistance in newly HIV-1 infected individuals documents a potential increase in the transmission of drug-resistant variants. Plasma samples...

html

Research Article: BMC Pharmacology

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:35 AM

Background Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania infantum. The failures of current treatment with pentavalent antimonials are partially...

html

Continuing HIV therapy in the ICU

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 04:37 AM

The risks and benefits of stopping antiretroviral therapy in patients admitted to the ICU are largely unmeasured. In many cases therapy has to be stopped, as parenteral preparations are...

html

Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:30 AM

Background: Axillary node status after induction chemotherapy for locally advanced breast cancer has been shown on multivariate analysis to be an independent predictor of relapse....

html