Catalog - Data.gov

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:01 AM

The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the...

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Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:00 AM

Because angiogenesis plays a major role in the perpetuation of inflammatory arthritis, we explored a method for selectively targeting and destroying new synovial blood vessels. Mice with...

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Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:26 AM

There is mounting evidence for a role of the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in inflammatory disease, including arthritis. In the present study, we examined...

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Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:35 AM

Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA....

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Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 04:38 AM

To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for...

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Association of MHC and rheumatoid arthritis: Regulatory role of HLA class II molecules in animal models of RA - studies on transgenic/knockout mice

Organization: U.S. Department of Health & Human Services
Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:33 AM

Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked...

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