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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:39 AM

Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 06:46 AM

The publication of the results of the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) and the termination of the doxazocin arm of the Antihypertensive and Lipid Lowering Treatment to...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:35 AM

An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:17 AM

The evidence base for drug treatment of hypertension is strong. Early trials using thiazide diuretics suggested a shortfall in prevention of coronary heart disease. The superiority of newer...

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