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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 06:17 AM

Asthma and associated phenotypes are complex traits most probably caused by an interaction of multiple disease susceptibility genes and environmental factors. Major achievements have occurred in...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 07:32 AM

The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 08:27 AM

Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06 | Harvested: September 06, 2025 at 09:33 AM

Background The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105→Val105 substitution...

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